Citalopram N-Oxide (CAS 63284-72-0) | conocido también como Citalopram Related Compound E | EsCitalopram EP Impurity H y 3-[5-cyano-1-(4-fluorophenyl)-3H-2-benzofuran-1-yl]-N | N-dimethylpropan-1-amine oxide | es una impureza de oxidación crítica en el control analítico de materias primas y productos intermedios de citalopram. Su detección y cuantificación se realizan por HPLC y LC-MS con métodos validados y estándares de referencia. Es esencial monitorizar su formación durante síntesis | purificación y almacenamiento | definir límites de especificación y evaluar estabilidad | perfiles de degradación e impacto potencial sobre la pureza y seguridad del producto farmacéutico.
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