2-Butyl-4-chloro-5-(hydroxymethyl)imidazole; 2-n-Butyl-4-chloro-5-(hydroxymethyl)imidazole; 5-Chloro-2-butyl-imidazole-4-methanol; Losartan EP Impurity A
Descripción
Losartan EP Impurity A (CAS 79047-41-9) | químicamente 2-butyl-4-cloro-5-(hydroxymethyl)imidazole | es una impureza estructural derivada del anillo imidazol presente en el perfil de impurezas de Losartan. Exhibe un sustituyente butilo en C2 | un cloro en C4 y un grupo hidroximetilo en C5 | características que afectan polaridad y comportamiento cromatográfico. Su identificación y cuantificación mediante técnicas analíticas como HPLC con detección UV | LC-MS y RMN es esencial para el control de calidad y la investigación de vías de degradación y reacción. La monitorización de esta impureza facilita el cumplimiento de especificaciones farmacéuticas y la optimización del proceso de síntesis.
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