5-(4′-Methylbiphenyl-2-yl)-1H-tetrazole Pottassium Salt
Sinónimos farmacopeicos
N/A
Otros sinónimos
N/A
SMILES
CC1=CC=C(C2=CC=CC=C2C3=N[N-]N=N3)C=C1.[K+]
Descripción
Losartan EP Impurity E (sal potásica) | CAS 860644-27-5 | es una impureza relacionada estructuralmente con el principio activo que puede formarse durante síntesis o degradación; su naturaleza iónica y mayor polaridad como sal potásica afectan solubilidad y comportamiento en fase líquida. La identificación y cuantificación se realizan habitualmente por HPLC con detección UV | LC-MS para confirmación de masa y resonancia magnética nuclear para verificación estructural. Su control es crítico para asegurar conformidad con límites reglamentarios ICH y monografías | evaluar estabilidad del lote y minimizar riesgos para la calidad del producto farmacéutico | por lo que se requiere estándar de referencia y procedimientos analíticos validados.
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