Seladelpar S-Sulfóxido es el producto de oxidación sulfoxídica de seladelpar y se clasifica formalmente como impureza de proceso oxidativa y posible marcador de degradación, no como un farmacóforo independiente. Con fórmula molecular C21H23F3O6S y masa molecular de 460.46 g/mol, presenta un centro de azufre estereogénico que puede originar isómeros de sulfoxido con relevancia configuracional. Su formación se asocia habitualmente con oxidación mediada por peróxidos durante la síntesis, el almacenamiento o la manipulación de muestras. La caracterización y cuantificación suelen requerir LC-MS/MS con espectrometría de masas de alta resolución, complementada por HPLC-UV y, cuando procede, RMN para confirmación estructural. La evaluación regulatoria se centra en el perfil de impurezas según ICH Q3A/Q3B.
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