Seladelpar S-Sulfoxide é o produto de oxidação sulfoxídica do seladelpar, classificado formalmente como impureza de processo oxidativa e possível marcador de degradação, e não como um farmacóforo independente. Com fórmula molecular C21H23F3O6S e massa molecular de 460.46 g/mol, possui um centro de enxofre estereogênico que pode originar isómeros de sulfoxido com relevância configuracional. Sua formação é tipicamente associada à oxidação mediada por peróxidos durante a síntese, o armazenamento ou o manuseio de amostras. A caracterização e a quantificação geralmente requerem LC-MS/MS com espectrometria de massa de alta resolução, frequentemente complementadas por HPLC-UV e, quando necessário, RMN para confirmação estrutural. A avaliação regulatória centra-se no perfil de impurezas segundo ICH Q3A/Q3B.
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