Trazodone EP Impurity F (HCl salt) | CAS 52605-52-4 | también referida como Trazodone BP Impurity F | Trazodone Related Compound F o Nefazodone Related Compound A (sal HCl) | es una impureza de piperazina identificada como Piperazine | 1-(3-clorofenil)-4-(3-cloropropil)- | monohidrocloruro que requiere monitorización en perfiles de impurezas. Su caracterización analítica se realiza mediante métodos indicativos de estabilidad como HPLC con detección UV | LC-MS y resonancia magnética nuclear para determinación de estructura y masa exacta. La formación suele originarse por rutas sintéticas secundarias o degradación durante síntesis y almacenamiento. Control | límites y estrategias de purga se definen conforme a guías regulatorias ICH y especificaciones de lote.
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