La impureza hidroxipropilo de trazodona, también denominada hidroxipropil clorofenilpiperazina, es una sustancia relacionada con trazodona asociada al fragmento piperazínico y al sustituyente 3-clorofenilo. El CAS 32229-98-4 corresponde a C13H19ClN2O, con peso molecular de 254,76 g/mol. Desde el punto de vista estructural, es un derivado de piperazina hidroxialquilado que puede formarse durante la síntesis o aparecer como arrastre de proceso procedente de intermedios y reacciones secundarias. Para diferenciar isómeros posicionales y niveles traza, la caracterización suele requerir LC-MS/MS, LC-HRMS y, tras derivatización, GC-MS. Su descripción es pertinente en estudios de control de impurezas farmacéuticas.
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