Mil = 5- methylene-L-isoleucine:4,10-Anhydro[N-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazol-4-yl]carbonyl]-L-leucyl-D-α-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-5-methylene-L-isoleucyl-D-phenylalanyl-L-histidyl-D-α-aspartyl-L-asparagine]
Pharmacopeial Synonyms
Bacitracin J2
Synonyms
N/A
Description
Bacitracin EP Impurity P, also designated Bacitracin J2, is a closely related cyclic dodecapeptide impurity associated with the bacitracin complex, arising primarily from biosynthetic microheterogeneity and peptide-chain variation during fermentation or subsequent purification. With molecular formula C66H103N17O16S and molecular weight 1422.70 g/mol, it contains the characteristic thiazoline-containing peptide architecture of bacitracin species and differs from the principal components by subtle sequence and oxidation-state features. Its characterization typically requires orthogonal RP-HPLC, LC-MS/MS, and high-resolution mass spectrometry, with peptide mapping or tandem fragmentation used to confirm identity and relative abundance in pharmacopeial impurity profiles.
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