Mil = 5- methylene-L-isoleucine:4,10-Anhydro[N-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazol-4-yl]carbonyl]-L-leucyl-D-α-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-5-methylene-L-isoleucyl-D-phenylalanyl-L-histidyl-D-α-aspartyl-L-asparagine]
Pharmacopeial Synonyms
Bacitracin J2
동의어
N/A
설명
Bacitracin EP Impurity P는 Bacitracin J2로도 표기되며, bacitracin 복합체에 포함되는 밀접한 관련의 고리형 dodecapeptide 불순물이다. 이는 주로 발효 과정에서의 생합성 미세이질성 및 후속 정제 단계의 펩타이드 사슬 변이에 의해 생성된다. 분자식 C66H103N17O16S, 분자량 1422.70 g/mol이며, bacitracin 계열의 특징인 황 함유 펩타이드 골격과 thiazoline 유사 모티프를 유지하지만, 주성분과는 미세한 서열 차이 및 산화 상태 차이로 구별된다. 확인과 정량에는 일반적으로 역상 HPLC, LC-MS/MS, 고분해능 질량분석, 펩타이드 매핑 및 탠덤 분해분석이 요구된다.
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