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15362-40-0Diclofenac EP Impurity A
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| Catalogue No.: | VL48003 |
|---|---|
| CAS No.: | 15362-40-0 |
| Mol. Formula: | C14H9Cl2NO |
| Mol. Weight: | 278.13 g/mol |
Additional information on CAS 15362-40-0
Parent drug
Diclofenac / AceclofenacIUPAC Name
1-(2,6-dichlorophenyl)-1,3-dihydro-2H-indol-2-onePharmacopeial Synonyms
Diclofenac Sodium EP Impurity A; Diclofenac Sodium BP Impurity A; Diclofenac potassium EP Impurity A; Diclofenac Related Compound A; Aceclofenac EP Impurity ISynonyms
Diclofenac Lactam; 1-(2,6-Dichlorophenyl)-2-indolinone; 1-(2,6-Dichlorophenyl)indolin-2-one; 1-(2,6-dichlorophenyl)-3H-indol-2-one; 1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one; 1-(2,6-Dichlorophenyl)oxindole;N-(2,6-Dichlorophenyl)-2-indolinone; 1,3-Dihydro-1-(2,6-dichlorophenyl)-2H-indol-2-oneSmiles
O=C1N(C2=C(Cl)C=CC=C2Cl)C3=C(C=CC=C3)C1InChI
InChI=1S/C14H9Cl2NO/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(17)18/h1-7H,8H2Shipping Condition
Ambient TemperatureCharacterization Data (Included)
HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).Additional Characterization Data
QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.Description
Diclofenac Lactam, CAS 15362-40-0, is the cyclic lactam oxindole impurity corresponding to the intramolecular cyclization product of diclofenac-related intermediates, also described as 1-(2,6-dichlorophenyl)indolin-2-one. With molecular formula C14H9Cl2NO and molecular weight 278.13 g/mol, it is a structurally defined related compound reported in diclofenac sodium and potassium pharmacopoeial monographs, as well as in aceclofenac impurity profiling. Its presence may arise from synthesis side reactions or thermal or oxidative transformation of precursor arylacetic acids. Determination typically requires LC-MS/MS or HPLC with diode-array detection, and confirmatory characterization by MS and NMR.References
Tong J. Gan Container: Current Medical Research and Opinion Year: 2010 Volume: 26 Issue: 7 DOI: 10.1185/03007995.2010.486301 URL: https://pubmed.ncbi.nlm.nih.gov/20470236/Request a Quote
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