N-Nitroso Eltrombopag

● Failure Report (NAP Test) Available

Catalogue No.:	VE0010123
CAS No.:	N/A
Mol. Formula:	C25H21N5O5
Mol. Weight:	471.5 g/mol

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Additional information on N-Nitroso Eltrombopag

Parent drug

Eltrombopag

IUPAC Name

3′-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazinyl)-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid

Pharmacopeial Synonyms

N/A

Other Synonyms

N/A

Smiles

O=C(C1=CC(C2=CC=CC(N(N=O)/N=C3C(C)=NN(C4=CC=C(C)C(C)=C4)C/3=O)=C2O)=CC=C1)O

InChI

InChI=1S/C25H21N5O5/c1-14-10-11-19(12-15(14)2)29-24(32)22(16(3)26-29)27-30(28-35)21-9-5-8-20(23(21)31)17-6-4-7-18(13-17)25(33)34/h4-13,31H,1-3H3,(H,33,34)/b27-22-

Description

N-Nitroso Eltrombopag is an N-nitroso derivative of the secondary amine present in Eltrombopag | which is a highly characterized reference material that meets stringent regulatory standards set for nitrosamine compounds | including those set by USP | EMA | JP | and BP. This nitroso standard is essential for a variety of applications | such as analytical method development | method validation (AMV) | and Quality Control (QC) | particularly in the context of Eltrombopag production. It is suitable for use in both Abbreviated New Drug Applications (ANDA) and New Drug Applications (NDA). This nitrosamine standard helps establish detection limits | quantify impurity levels | and ensure trace nitroso impurities in pharmaceutical products remain within FDA and EMA safety limits.

N-Nitroso-Eltrombopag: Synthesis Attempts and Failure Report (NAP Test)