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334981-12-3Almotriptan Related Compound C
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| Catalogue No.: | VL264003 |
|---|---|
| CAS No.: | 334981-12-3 |
| Mol. Formula: | C16H23N3O2S |
| Mol. Weight: | 321.44 g/mol |
Additional information on CAS 334981-12-3
Parent drug
AlmotriptanIUPAC Name
N-methyl-2-(5-((pyrrolidin-1-ylsulfonyl)methyl)-1H-indol-3-yl)ethan-1-amineSynonyms
N-Desmethyl AlmotriptanDescription
Almotriptan Related Compound C, also designated N-Desmethyl Almotriptan or Almotriptan EP Impurity A, is the nor-analogue of the sulfonamide triptan Almotriptan, CAS 334981-12-3. With molecular formula C16H23N3O2S and molecular weight 321.44 g/mol, it lacks the N-methyl substituent on the side-chain amine, a change that can arise as a synthetic precursor, process impurity, or metabolic N-dealkylation product. Its polar, basic character and chromatographic behavior typically require LC-MS/MS, LC-DAD, or high-resolution LC-MS for trace-level characterization and quantification. It is not a nitrosamine, but remains relevant in impurity profiling because structural analogues may affect impurity specification and related-substance control.References
Salva, Miquel, et al. “Identification of the Human Liver Enzymes Involved in the Metabolism of the Antimigraine Agent Almotriptan.†Drug Metabolism and Disposition, vol. 31, no. 4, Apr. 2003, pp. 404–11, https://doi.org/10.1124/dmd.31.4.404.Request a Quote
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