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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.
52490-15-0Amiodarone EP Impurity E
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| Catalogue No.: | VL1390006 |
|---|---|
| CAS No.: | 52490-15-0 |
| Mol. Formula: | C19H18O3 |
| Mol. Weight: | 294.34 g/mol |
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Additional information on CAS 52490-15-0
Parent drug
AmiodaroneIUPAC Name
(2-Butyl-benzofuran-3-yl)-(4-hydroxy-phenyl)-methanonePharmacopeial Synonyms
Amiodarone IP Impurity B; Amiodarone Related Compound ESynonyms
2-Butyl-3-(4-hydroxybenzoyl)benzofuran; (2-Butyl-benzofuran-3-yl)-(4-hydroxy-phenyl)-methanone; (2-Butylbenzofuran-3-yl)-(4-hydroxyphenyl)ketone; (2-butylbenzofuran-3-y1)(4-hydroxy-3,5-diiodophenyl) methanoneSmiles
CCCCc2oc1ccccc1c2C(=O)c3ccc(O)cc3InChI
InChI=1S/C19H18O3/c1-2-3-7-17-18(15-6-4-5-8-16(15)22-17)19(21)13-9-11-14(20)12-10-13/h4-6,8-12,20H,2-3,7H2,1H3Shipping Condition
Ambient TemperatureCharacterization Data (Included)
HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).Additional Characterization Data
QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.Description
Amiodarone EP Impurity E, also designated Amiodarone Related Compound E or Amiodarone IP Impurity B, is the ketonic benzofuran analog 2-butyl-3-(4-hydroxybenzoyl)benzofuran, CAS 52490-15-0, with molecular formula C19H18O3 and molecular weight 294.34 g/mol. This impurity reflects a structural related substance arising during synthesis or oxidative/photolytic transformation of amiodarone intermediates. As a non-iodinated aryl ketone, it is typically monitored as a process-related impurity rather than a classically genotoxic species. Determination generally requires stability-indicating reversed-phase HPLC with UV detection, confirmed by LC-MS or LC-MS/MS, and, when needed, orthogonal characterization by NMR or HRMS.References
Khan, M. A., et al. “Validation of a Stability Indicating LC Method for Amiodarone HCL and Related Substances.” Chromatographia, vol. 61, no. 11-12, May 2005, pp. 599–607, https://doi.org/10.1365/s10337-005-0554-3.Request a Quote
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