298220-99-2 : Desloratadine EP Impurity A (Free Base)
Also known as 11-fluoro-desloratadine, it is an impurity known to arise in the processing of desloratadine. Desloratadine is a tricyclic antihistamine, which is an orally active nonsedating, peripheral histamine H1-receptor antagonist. It has been useful as the active pharmaceutical ingredient in various drugs to treat allergy symptoms such as Clarinex.
Additional information on CAS 298220-99-2
(11RS)-8-chloro-11-fluoro-11-(piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, and add in synonym-11-Fluoro Desloratadine
8-Chloro-11-fluoro-6, 11-dihydro-11-(4-piperidinyl)-5H-benzo[5, 6]cyclohepta[1, 2-b]pyridine; Desloratadine EP Impurity A
Zheng, Jinjian, and Abu M. Rustum. “Rapid Separation of Desloratadine and Related Compounds in Solid Pharmaceutical Formulation Using Gradient Ion-Pair Chromatography.” Journal of Pharmaceutical and Biomedical Analysis, vol. 51, no. 1, Jan. 2010, pp. 146–52, https://doi.org/10.1016/j.jpba.2009.08.024.
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