298220-99-2 : Desloratadine EP Impurity A (Free Base)

298220-99-2 : Desloratadine EP Impurity A (Free Base)

Also known as 11-fluoro-desloratadine, it is an impurity known to arise in the processing of desloratadine. Desloratadine is a tricyclic antihistamine, which is an orally active nonsedating, peripheral histamine H1-receptor antagonist. It has been useful as the active pharmaceutical ingredient in various drugs to treat allergy symptoms such as Clarinex.

Additional information on CAS 298220-99-2

Catalogue No.

VL41010
CAS No.

298220-99-2
Molecular Formula

C₁₉H₂₀ClFN₂
Molecular Weight

330.83
Parent drug

Desloratadine
IUPAC Name

(11RS)-8-chloro-11-fluoro-11-(piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, and add in synonym-11-Fluoro Desloratadine
Synonyms

8-Chloro-11-fluoro-6, 11-dihydro-11-(4-piperidinyl)-5H-benzo[5, 6]cyclohepta[1, 2-b]pyridine; Desloratadine EP Impurity A
References

Zheng, Jinjian, and Abu M. Rustum. “Rapid Separation of Desloratadine and Related Compounds in Solid Pharmaceutical Formulation Using Gradient Ion-Pair Chromatography.” Journal of Pharmaceutical and Biomedical Analysis, vol. 51, no. 1, Jan. 2010, pp. 146–52, https://doi.org/10.1016/j.jpba.2009.08.024. ‌
Status

In-stock

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298220-99-2 : Desloratadine EP Impurity A (Free Base)

298220-99-2 : Desloratadine EP Impurity A (Free Base)
Catalogue No.

VL41010
CAS No.

298220-99-2
Molecular Formula

C₁₉H₂₀ClFN₂
Molecular Weight

330.83
Parent drug

Desloratadine
IUPAC Name

(11RS)-8-chloro-11-fluoro-11-(piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, and add in synonym-11-Fluoro Desloratadine
Synonyms

8-Chloro-11-fluoro-6, 11-dihydro-11-(4-piperidinyl)-5H-benzo[5, 6]cyclohepta[1, 2-b]pyridine; Desloratadine EP Impurity A
References

Zheng, Jinjian, and Abu M. Rustum. “Rapid Separation of Desloratadine and Related Compounds in Solid Pharmaceutical Formulation Using Gradient Ion-Pair Chromatography.” Journal of Pharmaceutical and Biomedical Analysis, vol. 51, no. 1, Jan. 2010, pp. 146–52, https://doi.org/10.1016/j.jpba.2009.08.024. ‌
Status

In-stock
ListName

Desloratadine EP Impurity A (Free Base)
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