2036-77-3: Dexamethasone EP Impurity J
Dexamethasone EP Impurity J (CAS No.: 2036-77-3) or 16a-Methyl-11-oxo Prednisolone is a metabolite of Dexamethasone which is a drug of choice for the treatment (particularly in preventing deafness)of infants and children with bacterial meningitis i.e inflammation of the protective membranes covering the brain and spinal cord.
17, 21-Dihydroxy-16α-methylpregna-1, 4-diene-3, 11, 20-trione
Xu, Qun. “Incorporating Solid-Phase Extraction into Compendial Procedures for the Determination of Dexamethasone and Impurities in Low-Dose Drug Products.” Journal of Pharmaceutical and Biomedical Analysis, vol. 175, Oct. 2019, p. 112773, https://doi.org/10.1016/j.jpba.2019.07.021.?Lebel, Marc H., et al. “Dexamethasone Therapy for Bacterial Meningitis.” New England Journal of Medicine, vol. 319, no. 15, Oct. 1988, pp. 964–71, https://doi.org/10.1056/nejm198810133191502.?