Dexamethasone Impurities

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
delta9 (11)-21- Ethyl formate Dexamethasone Dexamethasone

delta9 (11)-21- Ethyl formate Dexamethasone

VE008749 89561-92-2
Dexamethasone 17-Propionate Dexamethasone

Dexamethasone 17-Propionate

VE007346 15423-89-9
Dexamethasone 21-Palmitate Dexamethasone

Dexamethasone 21-Palmitate

VE0017565 14899-36-6
Dexamethasone 21-Phosphate Dexamethasone

Dexamethasone 21-Phosphate

VE0014496 312-93-6
Dexamethasone 21-Phosphate-D5 Dexamethasone

Dexamethasone 21-Phosphate-D5

DVE00490 N/A
Dexamethasone 21-Tertbutylacetate Dexamethasone

Dexamethasone 21-Tertbutylacetate

VE0014483 24668-75-5
Dexamethasone Acetate EP Impurity A Dexamethasone / Betamethasone

Dexamethasone Acetate EP Impurity A

VL273021 50-02-2
Dexamethasone Acetate EP Impurity C Dexamethasone

Dexamethasone Acetate EP Impurity C

VL273019 N/A
Dexamethasone Acetate EP Impurity D Dexamethasone

Dexamethasone Acetate EP Impurity D

VL273022 987-24-6
Dexamethasone Acetate EP Impurity E Dexamethasone

Dexamethasone Acetate EP Impurity E

VE005876 1524-94-3
Dexamethasone Acetate EP Impurity F Dexamethasone

Dexamethasone Acetate EP Impurity F

VE008475 2884-51-7
Dexamethasone Acetate EP Impurity G Dexamethasone

Dexamethasone Acetate EP Impurity G

VE008476 1597-78-0
Dexamethasone Acetate EP Impurity I Dexamethasone

Dexamethasone Acetate EP Impurity I

VE005877 3949-26-6
Dexamethasone Acid 17-O-Formyl Impurity Dexamethasone

Dexamethasone Acid 17-O-Formyl Impurity

VE005953 473273-04-0
Dexamethasone Desfluoro 11-Epimer Dexamethasone

Dexamethasone Desfluoro 11-Epimer

VE006401 78761-59-8
Dexamethasone EP Impurity A Dexamethasone

Dexamethasone EP Impurity A

VL273023 N/A
Dexamethasone EP Impurity B Dexamethasone

Dexamethasone EP Impurity B

VL273010 378-44-9
Dexamethasone EP Impurity C Dexamethasone

Dexamethasone EP Impurity C

VL273017 426-17-5
Dexamethasone EP impurity D Dexamethasone

Dexamethasone EP impurity D

VL273018 24916-90-3
Dexamethasone EP Impurity E Dexamethasone

Dexamethasone EP Impurity E

VL273016 13209-41-1
Dexamethasone EP Impurity F Dexamethasone

Dexamethasone EP Impurity F

VL273011 382-67-2
Dexamethasone EP Impurity G Dexamethasone

Dexamethasone EP Impurity G

VL273012 1177-87-3
Dexamethasone EP Impurity H Dexamethasone

Dexamethasone EP Impurity H

VL273024 10106-41-9
Dexamethasone EP Impurity I Dexamethasone

Dexamethasone EP Impurity I

VL273006 14622-47-0
Dexamethasone EP Impurity J Dexamethasone

Dexamethasone EP Impurity J

VE006073 2036-77-3
Dexamethasone EP Impurity K Dexamethasone

Dexamethasone EP Impurity K

VL273007 1809224-82-5
Dexamethasone Ethyl Ester Impurity Dexamethasone

Dexamethasone Ethyl Ester Impurity

VE006194 N/A
Budesonide for System Suitability CRS (Y0001148) Dexamethasone

Dexamethasone for peak identification CRS (Y0001593)

PVE00131 50-02-2
Dexamethasone Glyoxal Analog Dexamethasone

Dexamethasone Glyoxal Analog

VE009290 84449-15-0
Dexamethasone Glyoxal Impurity Dexamethasone

Dexamethasone Glyoxal Impurity

VE0010704 N/A
Dexamethasone Impurity Dexamethasone

Dexamethasone Impurity

VE0014485 N/A
Dexamethasone Impurity 12 Dexamethasone

Dexamethasone Impurity 12

VE0014488 N/A
Dexamethasone Impurity 13 Dexamethasone

Dexamethasone Impurity 13

VE0010105 N/A
Dexamethasone Impurity 14 Dexamethasone

Dexamethasone Impurity 14

VE009870 N/A
Dexamethasone Impurity 15 Dexamethasone

Dexamethasone Impurity 15

VE009872 N/A
Dexamethasone Impurity 16 Dexamethasone

Dexamethasone Impurity 16

VE009873 N/A
Dexamethasone Impurity 24 Dexamethasone

Dexamethasone Impurity 24

VE0014497 1800-15-3
Dexamethasone Impurity 25 (3Na Salt) Dexamethasone

Dexamethasone Impurity 25 (3Na Salt)

VE0014498 N/A
Dexamethasone Impurity 31 Dexamethasone

Dexamethasone Impurity 31

VE0014501 2964-79-6 (aldehyde form) | 4619-61-8 (hydrate form)
Dexamethasone Impurity 4 Dexamethasone

Dexamethasone Impurity 4

VE005952 1188271-71-7
Dexamethasone Impurity 4 Dexamethasone

Dexamethasone Impurity 4

VE0014481 N/A
Dexamethasone Impurity 7 Dexamethasone

Dexamethasone Impurity 7

VE005888 N/A
Dexamethasone Impurity 9 Dexamethasone

Dexamethasone Impurity 9

VE0014487 24510-54-1
Dexamethasone Oxetanone Dexamethasone

Dexamethasone Oxetanone

VE0014474 4089-36-5
Dexamethasone Phenylpropionate Dexamethasone

Dexamethasone Phenylpropionate

VE0014470 1879-72-7
Dexamethasone Phosphate Bisulfate Adduct Sodium Salt Dexamethasone

Dexamethasone Phosphate Bisulfate Adduct Sodium Salt

VE0012717 39005-10-2
Dexamethasone Phosphate Diester Dexamethasone

Dexamethasone Phosphate Diester

VE0014471 N/A
Dexamethasone Sodium Phosphate Diester Dexamethasone

Dexamethasone Sodium Phosphate Diester

VE006242 N/A
Dexamethasone Sodium Phosphate EP Impurity B Dexamethasone

Dexamethasone Sodium Phosphate EP Impurity B

VE0020568 360-63-4
Dexamethasone Sodium Phosphate EP Impurity B Dexamethasone

Dexamethasone Sodium Phosphate EP Impurity B

VE006236 151-73-5

Dexamethasone Related Compound

 

References

  • Dexamethasone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing WebMD.” Webmd.com, 2023, www.webmd.com/drugs/2/drug-1027-5021/dexamethasone
  • Johnson, Donavon B., et al. “Dexamethasone.” Nih.gov, StatPearls Publishing, 15 May 2022, www.ncbi.nlm.nih.gov/books/NBK482130/.
  • Demirhan, A., et al. “Antiemetic Effects of Dexamethasone and Ondansetron Combination during Cesarean Sections under Spinal Anaesthesia.” African Health Sciences, vol. 13, no. 2, Sept. 2013, https://doi.org/10.4314/ahs.v13i2.39.

FAQ’s

Does dexamethasone belong to a class of family ?

Dexamethasone comes under corticosteroid class of medicines. It reduces your immune system’s response to many illnesses, which helps to alleviate symptoms including swelling and allergic responses.

What is the mechanism action of dexamethasone?

It works by inhibiting neutrophils migration and lowering lymphocyte colony growth. The capillary membrane also gets less porous. Lysosomal membranes have become more stable. Vitamin A compounds, prostaglandins, and certain cytokines (interleukin-1, interleukin-12, interleukin-18, tumour necrosis factor, interferon-gamma, and granulocyte-macrophage colony-stimulating factor) are increased in the serum.

Is dexamethasone used as an antiemetic?

Dexamethasone is a corticosteroid that possesses antiemetic and anti-inflammatory properties. When taken in conjunction with other medications, dexamethasone has been shown to boost antiemetic or analgesic effectiveness, with minimal adverse effects when administered as a single agent.