5297-05-2: Digoxin EP Impurity F

Digoxin EP Impurity F (CAS No.: 5297-05-2) or Digoxigenin Bis-digitoxoside is yielded from anhydrous methanolic solution and is a metabolite of Digoxin which is a cardiac glycoside and does not decrease overall mortality among patients with heart failure and diminished left ventricular systolic function but helped to lower hospitalizations slightly.

Additional information

Catalogue No.

VE007269

CAS No.

5297-05-2

Molecular Formula

C35H54O11

Molecular Weight

650.8 g/mol

IUPAC Name

(3β, 5β, 12β)-3-[[2, 6-Dideoxy-4-O-(2, 6-dideoxy-β-D-ribo-hexopyranosyl)-β-D-ribo-hexopyranosyl]oxy]-12, 14-dihydroxycard-20(22)-enolide

Synonyms

Digoxigenin Bis-digitoxoside

References

Adamczyk, Maciej, and Jonathan Grote. “Regioselective Schiff’s Base Mediated Deglycosidation of Digitalis Glycosides. New Efficient Synthesis of Digoxigenin Bis-Digitoxoside and Digoxigenin Mono-Digitoxoside.” Tetrahedron Letters, vol. 36, no. 1, Jan. 1995, pp. 63–66, https://doi.org/10.1016/0040-4039(94)02212-t.?Rathore, Saif S., et al. “Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure.” New England Journal of Medicine, vol. 347, no. 18, Oct. 2002, pp. 1403–11, ht

Status

In-stock