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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

42399-49-5Diltiazem EP Impurity E

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Catalogue No.:	VL1080003
CAS No.:	42399-49-5
Mol. Formula:	C₁₆H₁₅NO₃S
Mol. Weight:	301.36 g/mol

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Additional information on CAS 42399-49-5

Parent drug

Diltiazem

IUPAC Name

(2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Pharmacopoeial Synonyms

Diltiazem Related Compound E

Other Synonyms

Des[3-Acetyl-5-(2-dimethylamino)ethyl] Diltiazem;(2S-Cis)-(+)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one;Cis-Hydroxy Lactam Diltiazem

Smiles

COC1=CC=C(C=C1)[C@H]2[C@H](C(=O)NC3=CC=CC=C3S2)O

InChI

InChI=1S/C16H15NO3S/c1-20-11-8-6-10(7-9-11)15-14(18)16(19)17-12-4-2-3-5-13(12)21-15/h2-9,14-15,18H,1H3,(H,17,19)/t14-,15+/m1/s1

Shipping Condition

Ambient Temperature

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Additional Characterization Data

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

Description

It is a reaction intermediate of Diltiazem which is a calcium antagonist. Diltiazem blocks the sluggish inward calcium current and thus prolongs the effective and functional refractory time of the atrioventricular node and intranodal (A-H) conduction.

References

Ishii, K., et al. “Assay of Four Stereoisomers of Desacetyl Diltiazem Hydrochloride. Application Toin Vitro Chiral Inversion Studies.” Chromatographia, vol. 43, no. 7-8, Oct. 1996, pp. 413–18, https://doi.org/10.1007/bf02271021.?Buckley, Micaela M. -T ., et al. “Diltiazem.” Drugs, vol. 39, no. 5, May 1990, pp. 757–806, https://doi.org/10.2165/00003495-199039050-00009.?