1168150-46-6: (E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
(E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6 carboxylate(CAS No.1168150-46-6) is an H2 receptor antagonist used to treat various types of ulcers and GERD. Nizatidine inhibits histamine in a competitive, reversible manner at histamine H2-receptors, notably those found in the gastric parietal cells. Nizatidine lowers stomach acid production by preventing histamine from acting on stomach cells. There was no observable antiandrogenic effect of nizatidine. The maximum duration of full-dose therapy for nizatidine-treated conditions is 8 weeks. It has been proven that nizatidine medication at a lower dose works well as maintenance therapy once active duodenal ulcers have healed.
Additional information on CAS 1168150-46-6
VE008883
1168150-46-6
C18H15NO4
309.32 g/mol
Nintedanib
(E)-Methyl 3-(Methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
N/A
El-Shaheny, Rania, et al. “Estimation of Nizatidine Gastric Nitrosatability and Product Toxicity via an Integrated Approach Combining HILIC, in Silico Toxicology, and Molecular Docking.” Journal of Food and Drug Analysis, vol. 27, no. 4, Oct. 2019, pp. 915–25, https://doi.org/10.1016/j.jfda.2019.08.001.
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