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953776-62-0N-[4-(4-Fluorophenyl)-5-methyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide

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Catalogue No.:	VE0026682
CAS No.:	953776-62-0
Mol. Formula:	C16H20FN3O2S
Mol. Weight:	337.41 g/mol

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Additional information on CAS 953776-62-0

Parent drug

Rosuvastatin

IUPAC Name

N-[4-(4-fluorophenyl)-5-methyl-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide

Smiles

FC1=CC=C(C2=C(C)C(C(C)C)=NC(N(C)S(C)(=O)=O)=N2)C=C1

InChI

InChI=1S/C16H20FN3O2S/c1-10(2)14-11(3)15(12-6-8-13(17)9-7-12)19-16(18-14)20(4)23(5,21)22/h6-10H,1-5H3

Description

N-[4-(4-Fluorophenyl)-5-methyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide (CAS 953776-62-0) is a process-related impurity encountered during synthesis of pyrimidinyl sulfonamide intermediates. It presents analytical challenges due to its close polarity and mass to target molecules, requiring orthogonal techniques such as HPLC with UV and MS detection, LC-MS/MS for confirmation, and 1H/13C NMR for structural verification. The impurity can arise from incomplete alkylation or sulfonamide formation and may increase under acidic or thermal stress. Controlled by optimized reaction conditions, purification steps, and validated analytical methods, monitoring limits and stability-indicating assays are recommended for specification setting and quality control.