N-Nitroso Desmethyl Sumatriptan Impurity
It is an impurity present in Sumatriptan, Sumatriptan is a serotonin receptor agonist, sumatriptan constricts cranial blood vessels and prevents the release of vasoactive peptides, also is an agonist of 5-HT1B and 5-HT1D. which inhibits the release of pro-inflammatory neuropeptides. Sumatriptan decreases carotid arterial blood flow and increases blood flow velocity in the internal carotid artery and middle cerebral artery. which is used to treat migraine.
Additional information on N-Nitroso Desmethyl Sumatriptan Impurity
VE0010179
N/A
C13H18N4O3S
310.4 g/mol
Sumatriptan
N-methyl-1-(3-(2-(methyl(nitroso)amino)ethyl)-1H-indol-5-yl)methanesulfonamide
N/A
Derry, C. J., Derry, S., & Moore, R. A. (2012). Sumatriptan (oral route of administration) for acute migraine attacks in adults. Cochrane Database of Systematic Reviews, 2019(5). https://doi.org/10.1002/14651858.cd008615.pub2
Under Development
