Sumatriptan Nitroso Impurity
It is an impurity present in Sumatriptan, Sumatriptan is an agonist of 5-HT1B and 5-HT1D. Sumatriptan is predominantly metabolized by monoamine oxidase. The metabolites are the inactive indole acetic acid and indole acetic acid glucuronide. Sumatriptan decreases carotid arterial blood flow, but increases blood flow velocity in the internal carotid artery and middle cerebral artery, Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.
Additional information on Sumatriptan Nitroso Impurity
VE0010178
N/A
C14H20N4O3S
324.4 g/mol
Sumatriptan
1-(3-(2-(Dimethylamino)ethyl)-1-nitroso-1H-indol-5-yl)-N-methylmethanesulfonamide
N/A
Derry, C. J., Derry, S., & Moore, R. A. (2014). Sumatriptan (all routes of administration) for acute migraine attacks in adults – overview of Cochrane reviews. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd009108.pub2
Under Development
