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86-87-3Naphazoline EP Impurity B

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Catalogue No.:	VL1510002
CAS No.:	86-87-3
Mol. Formula:	C12H10O2
Mol. Weight:	186.21

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Additional information on CAS 86-87-3

Parent drug

Naphazoline

IUPAC Name

(Naphthalen-1-yl)acetic acid

Pharmacopoeial Synonyms

1-Naphthylacetic Acid

Other Synonyms

2-(1-Naphthyl)acetic acid; Naphthalene-1-acetic acid

Smiles

O=C(O)CC1=C2C=CC=CC2=CC=C1

InChI

InChI=1S/C12H10O2/c13-12(14)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-7H,8H2,(H,13,14)

Description

Naphazoline EP Impurity B, CAS 86-87-3, corresponds to a neutral aromatic oxygenated impurity with formula C12H10O2 and molecular weight 186.21. Structurally, it is consistent with a benzylic/aryl ether-related degradant or process-related byproduct rather than a reactive mutagenic species. In pharmacopoeial contexts, such impurities are controlled as part of the related substances profile of naphazoline preparations. Determination typically requires orthogonal chromatographic separation by reversed-phase HPLC, with confirmatory characterization by LC-MS or GC-MS and, when needed, NMR comparison against a reference material to distinguish isomeric oxygenated aromatics.

References

Rajan, S. S. â€œ1-Naphthaleneacetic Acid.â€ Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, vol. 34, no. 3, Mar. 1978, pp. 998â€“1000, https://doi.org/10.1107/s0567740878004641 HURWITZ, P., and J. M. THOMPSON. â€œUSES of NAPHAZOLINE (PRIVINE(R)) in OPHTHALMOLOGY.â€ Archives of Ophthalmology, vol. 43, no. 4, Apr. 1950, pp. 712â€“17, https://doi.org/10.1001/archopht.1950.00910010723008.