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641571-11-1Nilotinib EP Impurity A
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| Catalogue No.: | VE006046 |
|---|---|
| CAS No.: | 641571-11-1 |
| Mol. Formula: | C11H10F3N3 |
| Mol. Weight: | 241.22 g/mol |
Additional information on CAS 641571-11-1
Parent drug
NilotinibIUPAC Name
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)anilinePharmacopeial Synonyms
Nilotinib Related Compound ASynonyms
Nilotinib Amino ImpuritySmiles
NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1InChI
NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1Description
Nilotinib EP Impurity A, also known as Nilotinib Related Compound A, in various pharmacopoeias, is a highly characterized standard. It meets strict regulatory requirements set by USP, EMA, JP, and BP, making it a crucial component in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Nilotinib.
References
Kondra, S. B., et al. “A Validated Stability-Indicative UPLC Method for Nilotinib Hydrochloride for the Determination of Process-Related and Degradation Impurities.” Journal of Chromatographic Science, vol. 52, no. 8, Sept. 2013, pp. 880–85, https://doi.org/10.1093/chromsci/bmt134. Tanaka, Chiaki, et al. “Effects of Rifampin and Ketoconazole on the Pharmacokinetics of Nilotinib in Healthy Participants.” The Journal of Clinical Pharmacology, vol. 51, no. 1, Jan. 2011, pp. 75–83, https://doi.org/10.1177/0091270010367428. Request a Quote
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