2119583-24-1: Nilotinib Ethylimidazole Analog

Status: In-stock

Nilotinib Ethylimidazole Analog (CAS No: 2119583-24-1) is an impurity present in Nilotinib which is a second-generation tyrosine kinase inhibitor indicated for the treatment of patients with chronic myeloid leukemia in the chronic phase and accelerated phase who are resistant to or intolerant of prior imatinib therapy.

Additional information on CAS 2119583-24-1

Catalogue No. VE008151
CAS No. 2119583-24-1
Molecular Formula C29H24F3N7O
Molecular Weight 543.54 g/mol
Parent drug Nilotinib
IUPAC Name N-(3-(4-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)benzamide
Synonyms N/A
Smiles CCC1=CN(C=N1)C2=CC(=CC(=C2)NC(=O)C3=CC(=C(C=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5)C(F)(F)F
References Kondra, S. B., et al. “A Validated Stability-Indicative UPLC Method for Nilotinib Hydrochloride for the Determination of Process-Related and Degradation Impurities.” Journal of Chromatographic Science, vol. 52, no. 8, Sept. 2013, pp. 880–85, https://doi.org/10.1093/chromsci/bmt134.?Hughes, Timothy, et al. “Impact of Baseline BCR-ABL Mutations on Response to Nilotinib in Patients with Chronic Myeloid Leukemia in Chronic Phase.” Journal of Clinical Oncology, vol. 27, no. 25, Sept. 2009, pp. 4204–10
Status In-stock

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2119583-24-1: Nilotinib Ethylimidazole Analog

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