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115973-28-9N,N-Didesmethyl Diltiazem
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| Catalogue No.: | VE006529 |
|---|---|
| CAS No.: | 115973-28-9 |
| Mol. Formula: | C20H22N2O4S |
| Mol. Weight: | 386.46 |
Additional information on CAS 115973-28-9
Parent drug
DiltiazemIUPAC Name
(2S-cis)-3-(Acetyloxy)-5-(2-aminoethyl)-2, 3-dihydro-2-(4-methoxyphenyl)-1, 5-benzothiazepin-4(5H)-oneSynonyms
N/ASmiles
CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN)C3=CC=C(C=C3)OCDescription
It is a blocker of CYP3A4 and a metabolite of Diltiazem which is a calcium blocker efficacious in the treatment of stable, variant, and unstable angina pectoris and mild to moderate systemic hypertension and also possesses a few favorable adverse effect profile.References
“Sutton, Dylan, et al. “Role of CYP3A4 in Human Hepatic Diltiazem N-Demethylation: Inhibition of CYP3A4 Activity by Oxidized Diltiazem Metabolites.” Journal of Pharmacology and Experimental Therapeutics, vol. 282, no. 1, American Society for Pharmacology and Experimental Therapeutics, July 1997, pp. 294–300, jpet.aspetjournals.org/content/282/1/294.short. ?Buckley, Micaela M. -T ., et al. “Diltiazem.” Drugs, vol. 39, no. 5, May 1990, pp. 757–806, https://doi.org/10.2165/00003495-199039050-00009.Request a Quote
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