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719300-59-1Olanzapine EP Impurity C (Chloride)

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Catalogue No.:	VL109003
CAS No.:	719300-59-1
Mol. Formula:	C18H22Cl2N4S
Mol. Weight:	397.37

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Additional information on CAS 719300-59-1

Parent drug

Olanzapine

IUPAC Name

1-(Chloromethyl)-1-methyl-4-(2-methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-yl)-piperazinium Chloride

Synonyms

Olanzapine N-Chloromethyl Chloride

Pharmacopeial Synonyms

Olanzapine BP Impurity C ;Chloromethyl Olanzapinium Chloride

Smiles

CC(S1)=CC2=C1NC3=CC=CC=C3N=C2N4CC[N+](C)(CCl)CC4.[Cl-]

InChI

InChI=1S/C18H22ClN4S.ClH/c1-13-11-14-17(22-7-9-23(2,12-19)10-8-22)20-15-5-3-4-6-16(15)21-18(14)24-13;/h3-6,11,21H,7-10,12H2,1-2H3;1H/q+1;/p-1

Description

Olanzapine EP Impurity C, also designated Olanzapine N-Chloromethyl Chloride and Olanzapine BP Impurity C (Chloride), CAS 719300-59-1, is a quaternary ammonium salt related to the olanzapine thiophene diazepine scaffold. It corresponds to a chloromethylated intermediate or process-related byproduct formed during alkylation or chlorination steps in synthesis, and may serve as a precursor to downstream substitution products. The molecular formula is C18H22Cl2N4S with molecular weight 397.37. Because ionic, nonvolatile species often require orthogonal characterization, determination typically relies on LC-MS/MS, HPLC with UV or MS detection, and, where appropriate, NMR and ion chromatography for chloride-associated species.

References

â€œSynthesis and Characterization of Impurities of an Anti-Psychotic Drug Substance, Olanzapine.â€ Arkivoc, vol. 2008, no. 11, Apr. 2008, p. 195, https://doi.org/10.3998/ark.5550190.0009.b19.