Olanzapine Impurities

Olanzapine is a second-generation atypical antipsychotic that works largely on dopamine and serotonin receptors.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
N-Desmethyl Olanzapine-D8 Olanzapine

N-Desmethyl Olanzapine-D8

DVE001143 786686-82-6
Olanzapine Acetyl Open Ring Analog Olanzapine

Olanzapine Acetyl Open Ring Analog

VE008122 1320360-87-9
Olanzapine Amino Methanone Impurity Olanzapine

Olanzapine Amino Methanone Impurity

VE008384 138564-61-1
Budesonide for System Suitability CRS (Y0001148) Olanzapine

Olanzapine CRS (Y0001370)

PVE00322 132539-06-1
Olanzapine EP Impurity A Olanzapine

Olanzapine EP Impurity A

VL109001 138564-59-7
Olanzapine EP Impurity B Olanzapine

Olanzapine EP Impurity B

VL109002 221176-49-4
Olanzapine EP Impurity C Olanzapine

Olanzapine EP Impurity C

VL109003 719300-59-1
Olanzapine EP Impurity D Olanzapine

Olanzapine EP Impurity D

VL109009 174794-02-6
Olanzapine F-PIN Impurity Olanzapine

Olanzapine F-PIN Impurity

VL109011 639460-79-0
Budesonide for System Suitability CRS (Y0001148) Olanzapine

Olanzapine for System Suitability CRS (Y0001380)

PVE00229 132539-06-1
Olanzapine Impurity 29 Olanzapine

Olanzapine Impurity 29

VE0018345 59591-86-5
Olanzapine Lactam Impurity Olanzapine

Olanzapine Lactam Impurity

VL109008 1017241-34-7
Olanzapine LIP 1 Acetyl Impurity Olanzapine

Olanzapine LIP 1 Acetyl Impurity

VL109012 935272-10-9
Olanzapine LIP 1-Dimer Impurity Olanzapine

Olanzapine LIP 1-Dimer Impurity

VL109014 N/A
Olanzapine N-desmethyl Impurity Olanzapine

Olanzapine N-desmethyl Impurity

VL109016 161696-76-0
Olanzapine N-ethyl Impurity Olanzapine

Olanzapine N-ethyl Impurity

VL109018 N/A
Olanzapine PIN 3H Impurity Olanzapine

Olanzapine PIN 3H Impurity

VL109019 873895-41-1
Olanzapine PIN-3 Impurity Olanzapine

Olanzapine PIN-3 Impurity

VL109013 138564-60-0
Olanzapine Related Compound 03 Olanzapine

Olanzapine Related Compound 03

VL109004 N/A
Olanzapine Related Compound 07 Olanzapine

Olanzapine Related Compound 07

VL109005 138564-58-6
Olanzapine Related Compound 08 Olanzapine

Olanzapine Related Compound 08

VL109006 N/A
Olanzapine Thio lactum Olanzapine

Olanzapine Thio lactum

VL109007 1017241-36-9
Olanzapine Thiohydroxymethylidene Olanzapine

Olanzapine Thiohydroxymethylidene

VE008103 1320360-86-8
Olanzapine-D3 Olanzapine

Olanzapine-D3

DVE001051 786686-79-1
Olanzapine-D8 Olanzapine

Olanzapine-D8

DVE001142 1093380-13-2
Olanzapine-N10-Glucuronide (Mixture of Diastereomers) Olanzapine

Olanzapine-N10-Glucuronide (Mixture of Diastereomers)

DVE001145 186792-80-3
2-Hydroxymethyl Olanzapine Olanzapine

2-Hydroxymethyl Olanzapine

VE0018343 174756-45-7
4-ethyl-5-methyl-2-((2-nitrophenyl)amino)isophthalonitrile Olanzapine

4-ethyl-5-methyl-2-((2-nitrophenyl)amino)isophthalonitrile

VE0010929 N/A
4-Fluoro Olanzapine Olanzapine

4-Fluoro Olanzapine

VE0018342 N/A

Ofloxacin Related Compound

It acts as an antagonist on dopamine D2 receptors in the mesolimbic pathway, preventing dopamine from acting at the post-synaptic receptor.

References

NHS Choices. Olanzapine – Brand Names: Zyprexa, Zentiva. 2023, www.nhs.uk/medicines/olanzapine/#:~:text=Olanzapine%20helps%20to%20manage%20symptoms,mania%20symptoms%20of%20bipolar%20disorder). Accessed 10 Apr. 2023. ‌

“Olanzapine and Fluoxetine (Oral Route) Side Effects – Mayo Clinic.” Mayoclinic.org, 2023, www.mayoclinic.org/drugs-supplements/olanzapine-and-fluoxetine-oral-route/side-effects/drg-20071357?p=1#:~:text=Olanzapine%20is%20an%20antipsychotic%20agent,only%20with%20your%20doctor’s%20prescription. Accessed 10 Apr. 2023.

Asaoka, Nozomi, et al. “Olanzapine Augments the Effect of Selective Serotonin Reuptake Inhibitors by Suppressing GABAergic Inhibition via Antagonism of 5-HT6 Receptors in the Dorsal Raphe Nucleus.” Neuropharmacology, vol. 95, Aug. 2015, pp. 261–68, https://doi.org/10.1016/j.neuropharm.2015.03.032. Accessed 10 Apr. 2023. ‌ ‌

FAQ

What is the purpose of the medication olanzapine?

Olanzapine is used to treat symptoms of mental illnesses such as seeing, hearing, feeling, or believing things that others do not, feeling particularly suspicious, or having jumbled thinking (schizophrenia) agitated or hyperactive, extremely enthusiastic, happy, or impetuous (mania symptoms of bipolar disorder)

Is olanzapine A antidepressant?

Olanzapine is an antipsychotic medication. Fluoxetine is an antidepressant and a member of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs).

Why does olanzapine inhibit serotonin?

Olanzapine enhances the action of selective serotonin reuptake inhibitors by reducing GABAergic inhibition via 5-HT6 receptor antagonism in the dorsal raphe nucleus. Neuropharmacology.