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1017241-34-7Olanzapine Lactam Impurity

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Catalogue No.:	VL109008
CAS No.:	1017241-34-7
Mol. Formula:	C17H20N4O2
Mol. Weight:	312.37 g/mol

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Additional information on CAS 1017241-34-7

Parent drug

Olanzapine

IUPAC Name

(3Z)-1,3-Dihydro-4-(4-methyl-1-piperazinyl)-3-(2-oxopropylidene)-2H-1,5-benzodiazepin-2-one

Pharmacopeial Synonyms

N/A

Synonyms

N/A

Smiles

O=C1NC2=CC=CC=C2N=C(N3CCN(C)CC3)/C1=C/C(C)=O

InChI

InChI=1S/C17H20N4O2/c1-12(22)11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)23/h3-6,11H,7-10H2,1-2H3,(H,19,23)/b13-11-

Description

Olanzapine lactam impurity, also referred to as olanzapine ketolactam impurity, is a structurally related oxidative degradation and process-related impurity of the thienobenzodiazepine antipsychotic scaffold. The compound, CAS 1017241-34-7, has molecular formula C17H20N4O2 and molecular weight 312.37 g/mol. Its lactam carbonyl indicates ring oxidation and rearrangement relative to the parent drug, consistent with impurity formation during synthesis or storage under oxidative conditions. Because such related substances can affect assay specificity and stability interpretation, characterization commonly relies on LC-MS/MS, HPLC with diode-array detection, and, when needed, NMR and high-resolution mass spectrometry for definitive structural assignment.

References

Rao, P. Sreenivasa, et al. “Identification of Oxidative Degradation Impurities of Olanzapine Drug Substance as Well as Drug Product. “Journal of Pharmaceutical and Biomedical Analysis, vol. 56, no. 2, Sept. 2011, pp. 413-18, https://doi.org/10.1016/j.jpba.2011.05.003.