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1809092-87-2Rosuvastatin (2S,4S)-Lactone

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Catalogue No.:	VE0026585
CAS No.:	1809092-87-2
Mol. Formula:	C22H26FN3O5S
Mol. Weight:	463.5 g/mol

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Additional information on CAS 1809092-87-2

Parent drug

Rosuvastatin

IUPAC Name

N-[4-(4-fluorophenyl)-5-[(E)-2-[(2S,4S)-4-hydroxy-6-oxooxan-2-yl]ethenyl]-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide

Pharmacopeial Synonyms

N/A

Synonyms

N/A

Smiles

O=C1O[C@H](/C=C/C2=C(C3=CC=C(F)C=C3)N=C(N(S(=O)(C)=O)C)N=C2C(C)C)C[C@H](O)C1

InChI

InChI=1S/C22H26FN3O5S/c1-13(2)20-18(10-9-17-11-16(27)12-19(28)31-17)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)32(4,29)30/h5-10,13,16-17,27H,11-12H2,1-4H3/b10-9+/t16-,17+/m0/s1

Description

Rosuvastatin (2S,4S)-Lactone (CAS 1809092-87-2) is a known lactone impurity and degradation product formed during synthesis or storage of rosuvastatin salts. Characterized by ring closure of the acid-alcohol motif, this stereospecific 2S,4S-lactone influences impurity profiles, stability and batch release testing. Analytical control typically employs validated HPLC-MS and NMR methods to quantify low-level presence and to monitor formation under forced degradation conditions. Understanding formation pathways guides optimization of process parameters, solvent selection and quench steps to minimize levels. Reporting and control strategies align with ICH guidelines for qualification and specification of pharmaceuticals.