Valproic Acid EP Impurity H, identified as valeronitrile (CAS 110-59-8), is a small aliphatic nitrile associated with the synthetic and degradative impurity profile of valproate-related substances. With molecular formula C5H9N and molecular weight 83.1 g/mol, it represents a volatile, structurally simple precursor-related impurity rather than a complex pharmacophore-derived degradant. Its presence is typically evaluated in the context of process-related carryover, side-reaction formation, or hydrolytic and oxidative transformation pathways. Because of its volatility and low polarity, headspace GC-MS, GC-FID, and confirmatory LC-MS/MS are commonly required for reliable trace-level identification and quantification.
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