5340-48-7: Valproic Acid EP Impurity J
Chemically known as 2,2-Dipropylpentanenitrile. It is an impurity of Valproic acid that is a class I Histone deacetylases inhibitor. It produces differentiation of carcinoma cells transformed into hematopoietic progenitor cells and leukemic blasts in patients with acute leukemia.
Additional information on CAS 5340-48-7
1-Butanecarboxylic Acid; NSC 406833; Propylacetic Acid; n-Pentanoic Acid; n-Valeric Acid
Alsarra, Ibrahim A., et al. “Valproic Acid and Sodium Valproate: Comprehensive Profile.” Profiles of Drug Substances, Excipients and Related Methodology, 2005, pp. 209–40, https://doi.org/10.1016/s0099-5428(05)32008-9. Zgouras, Dimitrios, et al. “Modulation of Angiogenesis-Related Protein Synthesis by Valproic Acid.” Biochemical and Biophysical Research Communications, vol. 316, no. 3, Apr. 2004, pp. 693–97, https://doi.org/10.1016/j.bbrc.2004.02.105.
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