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1180132-17-5Abemaciclib Impurity 1
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| カタログ番号: | VE0017758 |
|---|---|
| CAS番号: | 1180132-17-5 |
| 分子式: | C12H20N4 |
| 分子量: | 220.3 g/mol |
オンライン注文
に関する追加情報 CAS 1180132-17-5
親薬物
AbemaciclibIUPAC名
5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-aminePharmacopeial Synonyms
N/A同義語
2-Pyridinamine, 5-[(4-ethyl-1-piperazinyl)methyl]-; 2-Amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine; 5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine;SMILES
NC1=NC=C(CN2CCN(CC)CC2)C=C1InChI
InChI=1S/C12H20N4/c1-2-15-5-7-16(8-6-15)10-11-3-4-12(13)14-9-11/h3-4,9H,2,5-8,10H2,1H3,(H2,13,14)Shipping Condition
Ambient Temperature説明
Abemaciclib Impurity 1 (CAS 1180132-17-5) is a 2-pyridinamine derivative bearing a 5-(4-ethyl-1-piperazinyl)methyl substituent, also referenced as 2-amino-5-[(4-ethyl-1-piperazinyl)methyl]pyridine and 5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine. Its heterocyclic, multi-amine structure increases polarity and basicity relative to the parent API, which alters chromatographic retention, solubility and mass spectrometric ionization behavior. This process- and degradation-related impurity is critical for impurity profiling, method development and specification setting because of its potential impact on purity and stability. Characterization typically relies on orthogonal analytical approaches such as HPLC-UV and LC-MS to ensure accurate quantification and regulatory compliance.見積もり依頼
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