(2S,5R,6R)-6-((2R)-2-(2-Amino-2-(4-hydroxyphenyl)acetamido)-2-((2R,4S)-4-carboxy-5,5-dimethylthiazolidin-2-yl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Disodium Salt
同義語
N/A
説明
Amoxicillin Related Compound M は、アミノペニシリン骨格に由来するナトリウム塩不純物であり、分子式は C24H29N5Na2O8S2、分子量は 625.63 g/mol である。組成から、単純な酸化分解体ではなく、硫黄を含む二量体様の beta-ラクタム関連種と考えられる。不純物プロファイルでは、合成、保存、加水分解ストレスの過程で生じるカップリングまたは転位反応の産物として扱われることが多い。ペニシリン由来不純物は感作性や工程由来毒性の観点で評価対象となり得るため、管理された不純物評価の文脈で取り扱われる。検出と定量には、LC-MS/MS、高分解能 LC-MS、ならびにイオンペア法または HILIC による分離と DAD 検出が一般的に必要である.
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