Informações adicionais sobre o Amoxicillin Related Compound M
Fármaco de origem
Amoxicillin
Nome IUPAC
(2S,5R,6R)-6-((2R)-2-(2-Amino-2-(4-hydroxyphenyl)acetamido)-2-((2R,4S)-4-carboxy-5,5-dimethylthiazolidin-2-yl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Disodium Salt
Sinônimos
N/A
Descrição
Amoxicillin Related Compound M é uma impureza na forma de sal de sódio do arcabouço de aminopenicilina, com fórmula molecular C24H29N5Na2O8S2 e massa molecular de 625,63 g/mol. A composição indica uma espécie relacionada a beta-lactâmicos, de caráter dimérico e contendo enxofre, em vez de um simples produto de oxidação. Em perfis de impurezas, costuma ser interpretada como produto de reações de acoplamento ou rearranjo durante síntese, armazenamento ou estresse hidrolítico. Como impurezas derivadas de penicilinas podem apresentar relevância toxicológica por sensibilização ou origem de processo, sua presença é avaliada em um contexto regulatório de controle de impurezas. A detecção e a quantificação em traços normalmente exigem LC-MS/MS, LC-MS de alta resolução e separação cromatográfica ortogonal por par iônico ou HILIC com detecção por arranjo de diodos.
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