在庫拠点

New Jersey, USA
Czech Republic, EU
Mumbai, India

* 在庫状況によります

Documentation

MSDSをダウンロード

サンプルCOAをダウンロード

内容: HPLC、MASS/LC-MS、1H NMR、FT-IR、含量、構造解析レポート（SER）、および製品に応じた追加分析データ。

42399-49-5Diltiazem EP Impurity E

● 在庫あり

カタログ番号:	VL1080003
CAS番号:	42399-49-5
分子式:	C₁₆H₁₅NO₃S
分子量:	301.36 g/mol

見積もり依頼

RFQリストに追加

に関する追加情報 CAS 42399-49-5

親薬物

Diltiazem

IUPAC名

(2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

薬局方同義語

Diltiazem Related Compound E

Other Synonyms

Des[3-Acetyl-5-(2-dimethylamino)ethyl] Diltiazem;(2S-Cis)-(+)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one;Cis-Hydroxy Lactam Diltiazem

SMILES

COC1=CC=C(C=C1)[C@H]2[C@H](C(=O)NC3=CC=CC=C3S2)O

InChI

InChI=1S/C16H15NO3S/c1-20-11-8-6-10(7-9-11)15-14(18)16(19)17-12-4-2-3-5-13(12)21-15/h2-9,14-15,18H,1H3,(H,17,19)/t14-,15+/m1/s1

Shipping Condition

Ambient Temperature

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Additional Characterization Data

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

説明

It is a reaction intermediate of Diltiazem which is a calcium antagonist. Diltiazem blocks the sluggish inward calcium current and thus prolongs the effective and functional refractory time of the atrioventricular node and intranodal (A-H) conduction.

References

Ishii, K., et al. “Assay of Four Stereoisomers of Desacetyl Diltiazem Hydrochloride. Application Toin Vitro Chiral Inversion Studies.” Chromatographia, vol. 43, no. 7-8, Oct. 1996, pp. 413–18, https://doi.org/10.1007/bf02271021.?Buckley, Micaela M. -T ., et al. “Diltiazem.” Drugs, vol. 39, no. 5, May 1990, pp. 757–806, https://doi.org/10.2165/00003495-199039050-00009.?