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포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.

2378463-76-2Abiraterone N-Oxide Impurity

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카탈로그 번호:	VL830002
CAS 번호:	2378463-76-2
분자식:	C24H31NO2
분자량:	365.51 g/mol

견적 요청

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모약물

Abiraterone

IUPAC명

3-((3S, 8R, 9S, 10R, 13S, 14S)-3-hydroxy-10, 13-dimethyl-2, 3, 4, 7, 8, 9, 10, 11, 12, 13, 14, 15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine 1-oxide

약전 동의어

N/A

Other Synonyms

N/A

SMILES

C[C@@]12C(C3=C[N+]([O-])=CC=C3)=CC[C@@]1([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC2

Inchl

InChI=1S/C24H31NO2/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25(27)15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1

설명

Abiraterone N-Oxide Impurity is an impurity of Abiraterone acetate, a prodrug used in the treatment of castration-resistant prostate cancer. It acts by converting itself in vivo to abiraterone which inhibits androgen biosynthesis. It induces cancerous tissue as well as the natural production of androgens.

References

Mach, Samuel, et al. â€œEpoxidation Is the Preferred Pathway of First-Stage Metabolism of Abiraterone Acetate in Brown Bullhead (Ameiurus Nebulosus).â€ Environmental Science and Pollution Research, vol. 26, no. 34, Oct. 2019, pp. 34896â€“904, https://doi.org/10.1007/s11356-019-06568-y.