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New Jersey, USA
Czech Republic, EU
Mumbai, India

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포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.

1629778-77-3Abiratetone Succinate

● Under Development

카탈로그 번호:	VL830029
CAS 번호:	1629778-77-3
분자식:	C28H35NO4
분자량:	449.6 g/mol

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모약물

Abiraterone

IUPAC명

4-(((3S, 8R, 9S, 10R, 13S, 14S)-10, 13-dimethyl-17-(pyridin-3-yl)-2, 3, 4, 7, 8, 9, 10, 11, 12, 13, 14, 15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-oxobutanoic acid

약전 동의어

N/A

Other Synonyms

N/A

SMILES

O=C(O)CCC(O[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)C(C5=CC=CN=C5)=CC[C@@]4([H])[C@]3([H])CC=C2C1)=O

InChI

InChI=1S/C28H35NO4/c1-27-13-11-20(33-26(32)10-9-25(30)31)16-19(27)5-6-21-23-8-7-22(18-4-3-15-29-17-18)28(23,2)14-12-24(21)27/h3-5,7,15,17,20-21,23-24H,6,8-14,16H2,1-2H3,(H,30,31)/t20-,21-,23-,24-,27-,28+/m0/s1

설명

Abiratetone Succinate or 4-(((3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-oxobutanoic acid, it is a decreases in PSA levels, tumor shrinkage and is inhibitor of the steroidal enzyme CYP17A1. it is used in the treatment of prostate cancer.

References

Goldberg, Tamara, and Evangelina Berrios-Colon. â€œAbiraterone (Zytiga), a Novel Agent for the Management of Castration-Resistant Prostate Cancer.â€ Pharmacy and Therapeutics, vol. 38, no. 1, 1 Jan. 2013, pp. 23â€“26, www.ncbi.nlm.nih.gov/pmc/articles/PMC3628169/.