A impureza Phenylephrine Related Compound G (CAS 1094089-46-9) | identificada como (R)-2-((2-Hydroxy-2-(3-hydroxyphenyl)ethyl)(methyl)amino)acetic Acid | é um subproduto observado na síntese e na degradação da fenilefrina que pode comprometer o perfil de pureza | a estabilidade do lote e a conformidade com monografias farmacopéicas; sua presença em níveis traço exige estratégias analíticas rigorosas. A caracterização e quantificação são tipicamente realizadas por HPLC com detecção UV | LC-MS e RMN para identificação estrutural | enquanto o controle requer métodos validados | padrões de referência e investigação das vias de formação para reduzir riscos toxicológicos e regulatórios.
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