Amoxicilloic Acid Dimers 1 & 2; Oligomers of Penicilloic Acids of Amoxicillin; Oligomers of Penicilloic Acids of Amoxicillin; (4S)-2-(1-((R)-2-amino-2-(4-hydroxyphenyl)acetamido)-2-(((1R)-2-((carboxy((4S)-4-carboxy-5,5-dimethylthiazolidin-2-yl)methyl)amino)-1-(4-hydroxyphenyl)-2-oxoethyl)amino)-2-oxoethyl)-5,5-dimethylthiazolidine-4-carboxylic Acid;
Descrição
Amoxicillin EP Impurity K (CAS 2088961-38-8) | também referida como Amoxicilloic Acid Dimers 1 & 2 e Oligomers of Penicilloic Acids of Amoxicillin | é uma impureza de degradação oligomérica formada por dimerização dos ácidos peniciloicos resultantes da abertura do anel beta-lactâmico. Caracteriza-se por massa molecular elevada | polaridade aumentada e sinais distintos em LC-MS e RMN | sendo crítica para controle de qualidade de lotes farmacêuticos. A sua quantificação requer métodos validados de cromatografia líquida de alta eficiência e espectrometria de massa | com limites de identificação e quantificação estabelecidos conforme monografias e práticas regulatórias. Estudos de estabilidade e otimização de formulação mitigam a sua formação.
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