A 6-iodoamilorida (CAS 60398-23-4) é um análogo halogenado da amilorida, com fórmula molecular C6H8IN7O e massa molar de 321,08 g/mol. Como derivado iodado posicional do arcabouço diurético pirazina-guanidínio, é geralmente tratada como impureza de origem sintética ou análogo relacionado ao processo, decorrente de iodação eletrofílica ou de controle incompleto de substituição durante a fabricação. Sua estrutura polar e policatiônica, associada ao átomo pesado de iodo, modifica retenção e ionização em relação à amilorida. A caracterização e a quantificação em nível traço normalmente exigem LC-MS/MS, espectrometria de massas de alta resolução e métodos ortogonais por LC-UV, com avaliação de padrões isotópicos e íons fragmento.
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