Amoxicilina trihidratada (CAS 61336-70-7) é uma impureza estrutural derivada da amoxicilina | caracterizada pelo anel beta-lactâmico sensível à hidrólise e pelo anel fenólico p-hidroxil substituído. Na forma trihidratada apresenta cristalinidade e perfil de solvatação que afetam solubilidade e estabilidade. Analiticamente exige técnicas como LC-MS | RMN e espectroscopia IR para confirmação estrutural e quantificação | com detecção UV favorecida pelo cromóforo aromático. Em cromatografia reversa tende a reter menos por maior polaridade | sendo separada com melhor resolução por condições ajustadas de fase móvel ou por HILIC. Controlo de umidade e temperatura é crítico devido à susceptibilidade à degradação do anel beta-lactâmico.
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