Impureza 7′-metil-2′-propyl-1H | 3’H-2 | 5′-bibenzo[d]imidazol (CAS 884330-09-0) | também referida como Telmisartan-Desmethyl Dibenzimidazole | é uma impureza processual associada à síntese do núcleo dibenzimidazol. Caracteriza-se por similaridade estrutural com o API e pode surgir por desmetilação parcial ou reações secundárias durante etapas de construção do anel. A sua identificação e quantificação requerem técnicas analíticas sensíveis | como HPLC acoplada a MS e verificação por RMN | para distinguir isômeros e traços. O controlo desta impureza passa por otimização de condições reacionais | etapas de purificação e estabelecimento de especificações de acordo com diretrizes ICH | minimizando risco para qualidade e segurança do produto.
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![7'-methyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole](https://veeprho.com/wp-content/uploads/2023/06/7-methyl-2-propyl-1H-3-H-2-5-bibenzo-d-imidazole-sqr.png "7'-methyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole")
