Telmisartan-Dibromo Impurity (CAS 1352492-08-0) é uma impureza identificada no processo de síntese e degradação de telmisartan | caracterizada por substituição dibromada na estrutura do fármaco. Seu perfil analítico inclui retenção distinta em HPLC-UV | massa molecular confirmada por espectrometria de massas e padrões de deslocamento em RMN compatíveis com dois átomos de bromo. A presença desta impureza exige monitoramento por métodos validados e definição de limites conforme ICH Q3A/Q3B para garantir conformidade de especificações. Estudos de forçamento de degradação e controle de processo permitem reduzir sua formação durante síntese e purificação.
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