O ácido alanilglutâmico, CAS 13187-90-1, é uma impureza dipeptídica definida, constituída por resíduos de alanina e ácido glutâmico, com fórmula molecular C8H14N2O5 e massa molecular de 218.21 g/mol. Está geralmente associado a reações secundárias de acoplamento peptídico, desproteção incompleta ou arraste parcial de sequência durante a síntese de derivados de aminoácidos e substâncias ativas relacionadas. Como espécie zwitteriônica polar, apresenta baixa volatilidade e é tipicamente caracterizado por LC-MS/MS ou HILIC acoplada à MS de alta resolução, com confirmação ortogonal por troca iônica ou LC com derivatização. Regulatoriamente, é tratado como impureza de processo, sem alerta genotóxico intrínseco.
Referências
Schiesel, Simone, et al. “Quantitative High-Performance Liquid Chromatography–Tandem Mass Spectrometry Impurity Profiling Methods for the Analysis of Parenteral Infusion Solutions for Amino Acid Supplementation Containing L-Alanyl-l-Glutamine.†Journal of Chromatography A, vol. 1259, Oct. 2012, pp. 111–20,  https://doi.org/10.1016/j.chroma.2012.01.020.
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