El ácido alanylglutámico, CAS 13187-90-1, es una impureza dipeptídica definida compuesta por residuos de alanina y ácido glutámico, con fórmula molecular C8H14N2O5 y masa molecular de 218.21 g/mol. Suele asociarse con reacciones secundarias de acoplamiento peptídico, desprotección incompleta o arrastre parcial de secuencia durante la síntesis de derivados de aminoácidos y principios activos relacionados. Como especie zwitteriónica polar, presenta baja volatilidad y normalmente se caracteriza mediante LC-MS/MS o HILIC acoplada a MS de alta resolución, con confirmación ortogonal por intercambio iónico o métodos LC con derivatización. En contexto regulatorio se considera una impureza de proceso, sin alerta genotóxica inherente.
Referencias
Schiesel, Simone, et al. “Quantitative High-Performance Liquid Chromatography–Tandem Mass Spectrometry Impurity Profiling Methods for the Analysis of Parenteral Infusion Solutions for Amino Acid Supplementation Containing L-Alanyl-l-Glutamine.†Journal of Chromatography A, vol. 1259, Oct. 2012, pp. 111–20,  https://doi.org/10.1016/j.chroma.2012.01.020.
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