Amoxicillin Related Compound 2 é uma impureza relacionada à amoxicilina | identificada sob CAS 6324-01-2 | relevante para controle de qualidade e avaliação de estabilidade. Essa impureza pode originar-se de degradação da cefalosporoína beta-lactâmica durante síntese | armazenamento ou processamento | afetando perfil de pureza e potencial toxicidade. A sua caracterização emprega HPLC acoplada a detectores UV e espectrometria de massa para determinação estrutural e quantificação | complementada por ensaios de impurezas de processo. Estratégias de controle incluem otimização de condições reacionais | purificação por cromatografia e limites de especificação conforme diretrizes regulatórias. Monitoramento contínuo garante conformidade e segurança do produto final.
Referências
Valvo, L., et al. “Development of a Simple Liquid Chromatographic Method with UV and Mass Spectrometric Detection for the Separation of Substances Related to Amoxicillin Sodium.†Journal of Chromatography A, vol. 797, no. 1-2, Feb. 1998, pp. 311–16, https://doi.org/10.1016/s0021-9673(97)00952-7 Zhu, Yongxin, et al. “Evaluation of Liquid Chromatography Methods for the Separation of Ampicillin and Its Related Substances.†Journal of Pharmaceutical and Biomedical Analysis, vol. 14, no. 5, Mar. 1996
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