Impureza Citalopram EP Impurity F (CAS 64169-39-7) | também referida como Citalopram Related Compound H | Citalopram Bromo Analog ou 5-Bromo-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1 | 3-dihydroisobenzofuran | é um subproduto halogenado observado em sínteses e processos de purificação do citalopram. Caracteriza-se por presença de bromo no anel isobenzofurano e representa risco de contaminação por via de reações de bromação ou impurezas de reagentes. A sua monitorização é crítica em controles de qualidade e estudos de estabilidade. Métodos analíticos recomendados incluem HPLC acoplado a detecção UV e LC-MS para identificação e quantificação com limites de quantificação adequados para conformidade com monografias e avaliações toxicológicas.
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