A Impureza Descloro da Dapagliflozina (CAS 2444702-80-9) é um análogo estrutural relacionado ao processo sintético da dapagliflozina, no qual o substituinte cloro aromático esteve ausente durante a síntese ou foi removido por transformações anteriores, originando uma impureza deshalogenada com fórmula molecular C21H26O6 e massa molecular de 374.43 g/mol. Como impureza associada a um inibidor de SGLT2 não halogenado, é relevante para o perfil de impurezas e para a avaliação das vias reacionais em intermediários e lotes de substância ativa. Sua caracterização geralmente exige LC-MS/MS para confirmação de massa, LC-MS de alta resolução para massa exata e HPLC-UV ou RMN ortogonais para discriminação estrutural.
Referências
Iwashige, Tadahiro, and Hiromichi Saeki. “Rearrangement of D-Glucofuranoside to L-Arabino-Hexofuranoside : Synthesis of 6-Deoxy-6-Nitro-L-Arabino-Hexofuranoside through L-Arabino-Pentodialdo-1, 4-Furanoside from D-Glucose or L-Arabinose.†Chemical and Pharmaceutical Bulletin, vol. 15, no. 1, 1967, pp. 132–35, https://doi.org/10.1248/cpb.15.132.?
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