A impureza Dimetil Azelato (CAS 1732-10-1) apresenta perfil químico e físico que exige controle analítico rigoroso em matrizes orgânicas. Como é um éster dialquílico do ácido azelaico, sua presença pode alterar propriedades como ponto de ebulição, polaridade e estabilidade oxidativa, impactando qualidade e desempenho do lote. É detectável e quantificável por cromatografia gasosa acoplada a espectrometria de massas e por HPLC com detecção UV, exigindo limites de quantificação baixos e validação de método para linearidade, precisão e recuperação. Procedimentos de amostragem, condições de armazenamento e estudos de degradação são recomendados para minimizar variação e assegurar conformidade com especificações.
Referências
Nazzaro-Porro, Marcella. “Azelaic Acid.†Journal of the American Academy of Dermatology, vol. 17, no. 6, 1 Dec. 1987, pp. 1033–1041, www.sciencedirect.com/science/article/abs/pii/S0190962287702941, 10.1016/S0190-9622(87)70294-1. Accessed 28 Jan. 2022.
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